Monday, January 30, 2023

Adam's Curse - Bryan Sykes

This was a great read, in my quest to catch up with the origins of DNA science.  The author, Bryan Sykes, first got my attention with his book, Seven Daughters of Eve.  It's entertaining despite all the scientific details.  I've got another one of his books left to read.

Quotes:

"It is no secret that, underneath it all, men are basically genetically modified women."

"..the accumulated rate of non-paternity events...comes to 1.3 % non-paternity events per generation."

"Only men get haemophilia and only men are colour-blind.  Because the genes for both haemophilia and colour-blindness are carried on the X-chromosome."

Published: 2018  Read: January 2023  Genre: Science 

Friday, January 27, 2023

Who We Are and How We Got Here - David Reich

Sub-title: Ancient DNA and the New Science of the Human Past

My Advanced Genetic Genealogy study group recommended this one when we were discussing books related to mitochondrial DNA (mtDNA).  It took me a while to get through.  The first two-thirds was a lot of science of whole genome sequencing (WGS) of DNA from ancient remains and covered how Europe, India, America and Asia were populated and how they tied back to Africa.  It provides a significant update of studies of ancient DNA.

The last part of the book covered how genomic studies reveal inequality, race, identity and concludes with a discussion of the future of ancient DNA. The author described how statistical genetics are applied to determine population origination and migration.  I enjoyed reading it and look forward to future developments in the field.

Quotes and Notes:

[explanation of DNA segments] "Females create an average of about 45 new splices when producing eggs while males create about 26 new splices when producing sperm, for a total of about 71 onew splices per generation."

[population bottlenecks] "European ancestry...Ashkenazi Jews, Finns, Hutterites, Amish, French Canadians of the Saguenay-Lac-St.-Jean region and others--have been the subject of endless and productive study by medical researchers."

"...around one-third of Indian jati [caste system] groups descend from bottlenecks as strong or stronger than those that occurred in Ashkenazi Jews or Finns."

[genomics of inequality] "The archaeologist Marija Gimbutas...argues that the arrival of the Yamnaya [nomadic Steppe culture dating to 3300-2600 BCE] in Europe heralded a shift in the power relationship between the sexes. "

"Between 2011 and 2015...23andMe provided customers with an estimate of their proportion of Neanderthal ancestry. The measurement made by the test was highly inaccurate, however.  Later, 23andMe changed its report....however the company continues to provide its customers with a ranking of the number of Neanderthal-derived mutations they carry.  This ranking, too, does not provide strong evidence that customer have inherited more Neanderthal DNA than their population average."

"At the rate at which ancient DNA data are now being produced...a single laboratory will be producing genome-wide data from thousands of ancient people a year.  This will make it possible to provide a detailed chronicle of how human populations have changed over recent millennia."

Published:  2018  Read: January 2023  Genre: Science

Tuesday, January 17, 2023

The Hummingbird's Daughter - Luis Alberto Urrea

I'd added this book to my reading list after hearing the author speak at the Nashville book festival several years ago.  I enjoyed his other book that he spoke about at the festival House of Broken Angels . This one was highly praised as well.  

It tells the fictionalized story of the author's great-aunt, Tereista, an illegitimate daughter of a a powerful ranch owner in 1870s Mexico, who becomes a healer recognized as a saint.

It took me months to slog through this book and I gave up about page 300, with 200 more to go.  It was too depressing reading of the atrocities during the war in Mexico and the poverty of the people.  

Published:   June 2006 Read:  January 2023  Genre: Fiction

Tuesday, January 10, 2023

A Suitable Companion for the End of Your Life - Robert McGill

My second post-pandemic themed book, this is a dark look into the future where a plague can only be avoided by being "flatpacked"  --- preserved alive for future inflation (as in literally being inflated like a balloon), albeit without memories.  The main character, Regan, is thoroughly unlikeable, even to herself, and the flatpacks she orders to end her life lead her to an alternative she'd not imagined.  Is obliviousness a true escape from death?  

I felt the story was contrived and incomplete, posing questions without answers.  I can't say I recommend it though I think it will be sticking with me for awhile.

Published: 2022   Read: January 2023  Genre:Science Fiction

Lucy by the Sea - Elizabeth Strout

Looking at YouTube videos of the best books of 2022 from various reviewers, I found this one mentioned as one of the post pandemic themed reads.  I'd read the author's Olive Kitteridge  back in 2008 and enjoyed it.  Her books connect her characters across the stories, Olive playing a minor role in this one.

Lucy, her main character was not someone I liked very much.  She's 60ish and recently widowed from her second husband.  She's an insipid worrier that I thought might be experiencing the beginnings of dementia. The story is told from her point of view, where her first husband, a scientist, insists she and their daughters leave New York as the pandemic hits, taking off for Maine, hence the title.  

It's a painfully reminiscent chronicling of our lives during Covid-19 and there are recognizable reactions to our real life experiences during its scourge.  Her reflective, passive acceptance of what has happened in her life and what happens during their time in isolation is in contrast to the reactions of those surrounding her. 

In the end I found the story soothing and comforting, a looking back on what some have survived. I appreciated the story's handling of our fears and doubts and the changes it as wrought on our ourselves, our families and our lives.

Quotes:

"I had often thought before: that there had been a last time--when they were little--that I had picked up the girls.  This had broken my heart, to realize that you never know the last time you pick up a child."

"My mother, because she was my mother, had great gravity in my young life.  In my whole life.  I did not know who she was, and I did not like who she had been.  But she was my mother, and so some part of me had continued to believe things she had said."

"Because I would never have had an affair, I thought William would not either.  I had been thinking like myself."

Published: 2000  Read: Jan 2023 Genre: Fiction 

Saturday, January 7, 2023

Escape Into Meaning - Evan Puschak

 Sub-title: Essays on Superman, Public Benches, and other Obsessions

I found this book through the author's Youtube site "The Nerdwriter".  He reviews movies and books and discusses issues in what is described as "video essays".  For me his channel provides a perspective on the thinking and ideas of a younger generation (he's 34 years old).  I was repeatedly struck by my lack of familiarity with his references from his childhood and life today because I am a different generation and have not been around people his age very much.  I did connect, however, with his analysis of today's digital, virtual, internet world and its destructive impact on our lives.

Quotes:

"From Emerson [Ralph Waldo Emerson] I learned two fundamental truths: first that we learn by expressing, not by thinking, which is to say that knowledge doesn't really exist until you can write it down."

"The modern world obliterates restraint.  The internet obliterates the time between experiences....'we [streaming services] are really competing with sleep on the margin'".

"The internet of today, designed to make you a permanent input, does more than just steal time from you; it erodes your agency and substitutes internet-awareness for self-awareness.  Those are the three things--time, agency, and self-awareness--that we use to construct our identities.  Without them, sense of self weakens, identity destabilizes, and the result is what we see in the research and feel in ourselves: stress, anxiety, or worse."

"To feel that someone really wants to understand and help you is a gift, and once you have it, you can't help but pass it on."

" A big undertaking, whether it's writing a novel, starting a business, or nurturing a relationship, requires emotional stability.  But our emotions aren't stable, so the best we can do is cultivate a bird's-eye view on ourselves to remind us of the colored lens [feeling] we're seeing through." 

Published: 2022  Read:   January 2023  Genre: Essay