Showing posts with label mitochondrial DNA. Show all posts
Showing posts with label mitochondrial DNA. Show all posts

Monday, January 30, 2023

Adam's Curse - Bryan Sykes

This was a great read, in my quest to catch up with the origins of DNA science.  The author, Bryan Sykes, first got my attention with his book, Seven Daughters of Eve.  It's entertaining despite all the scientific details.  I've got another one of his books left to read.

Quotes:

"It is no secret that, underneath it all, men are basically genetically modified women."

"..the accumulated rate of non-paternity events...comes to 1.3 % non-paternity events per generation."

"Only men get haemophilia and only men are colour-blind.  Because the genes for both haemophilia and colour-blindness are carried on the X-chromosome."

Published: 2018  Read: January 2023  Genre: Science 

Saturday, December 17, 2022

A Short History of Humanity - Johannes Krause and Thomas Trappe

 Sub-title: A New History of Old Europe

Krause is an archaeogeneticist, an archaeologist who focuses on the ancient DNA discovered in archeological digs. His co-author, Thomas Trappe is a German health journalist.  The book re-visits previously recovered remains from ancient origins to apply the latest DNA technical analysis tools.  Using this updated information, some discoveries are reaffirmed, and others updated or revised entirely.  As explained in recent articles where ancient (13th-14th century) remains are analyzed, in some cases, entirely new discoveries are made.  The book can get a bit technical on the science used.  I was fascinated with the process and how our understanding of ancient migration patterns, languages, and diseases can be tracked using DNA.

Quotes:

p 27 "A mutation reliably appears in mtDNA only every 3,000 years on average...this means that for 3,000 years, the mtDNA passed down along a female line is identical."

p 27 "The mtDNA of all living modern human beings can be traced back to a single female ancestor...she lived around 160,000 years ago...mitochondrial Eve. A male counterpart, chromosomal Adam, lived almost 200,000 years before mitochondrial Eve however, so we can say with certainty that they weren't a couple."

p 41 "Some Europeans and many South Asians, inherited a gene that causes a much stronger immune reaction to a COVID-19 virus infection.  Carriers of the Neanderthal gene are three times more likely to die from this newly emerged virus."

p. 144 "Using DNA analysis, we were able to identify men from five consecutive generations in some family graves, but we did not find a single adult female descendant, confirming that the daughters of the families were likely sent away before they became adults.  Evidently sons, instead, inherited the farmsteads from their fathers. ..In all, this genetic data reveals patriarchal and hierarchical structures that became widespread during the Bronze Age and continue to shape some familial and social conventions even today."

p. 167..." in 2012, the US Dept. of Defense launch the Defense Threat Reduction Agency's Algorithm Challenge...to develop a computer algorithm that would quickly discover and identify bacterial and viral DNA.  Daniel Huson, a specialist in bioinformatics, developed a related algorithm that could match a billion DNA sequences to their organism of origin within 24 hours..instead of weeks.


Published:  2021  Read: December 2022  Genre: History, Science